Title: Neuritogenic Effect of Standardized Extract of Centella Asiatica Eca233 on Human Neuroblastoma Cells
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Neuritogenic effect of standardized extract of Centella asiatica ECa233 on human neuroblastoma cells
BACKGROUND In order to gain insight into neuroprotective effects of ECa 233, a standardized extract of Centella asiatica, previously demonstrated in animal models of memory impairment induced by transient global ischemia or intracerebroventricular injection of β-amyloid, the effect of ECa 233 on neurite outgrowth of human IMR-32 neuroblastoma cell line was investigated. METHODS Cells were see...
متن کاملNeurotrophic activity of standardized extract of Centella asiatica ECa233 on human neuroblastoma cells
Inter-disciplinary Program in Physiology, Graduate School, Chulalongkorn University, Bangkok, Thailand. Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand. Cell-based Drug and Health Product Development Research Unit., Chulalongkorn University, Bangkok, Thailand. Faculty of Dentistry, Mahidol University, Bangkok, Thailand D...
متن کاملNitric Oxide radical scavenging assay of bioactive compounds present in methanol Extract of Centella asiatica
Centella asiatica L. has been used as a medicinal herb for thousands of years in India, China, Sri lanka, Nepal and Madagascar. Centella asiatica is one of the chief herbs for treating skin problems, to heal wounds, for revitalizing the nerves and brain cells, hence primarily known as a "Brain food" in India. In India, it is described under the name of Mandukaparni and used in Ayurveda medicine...
متن کاملBiological Activities and Stability of a Standardized Pentacyclic Triterpene Enriched Centella asiatica Extract
Pentacyclic triterpenes, mainly, asiatic acid, madecassic acid, asiaticoside, and madecassoside are the active constituents of Centella asiatica. A pentacyclic triterpene enriched C. asiatica extract (PRE) was prepared and standardized to contain a total pentacyclic triterpenes not less than 65% w/w. This work was focused on determination of antiinflammatory, antioxidant, and tyrosinase inhibit...
متن کاملEffect of Centella asiatica L. extract Against Ethinylestradiol- induced Geno toxic Damage on Cultured Human Lymphocytes
In this study the effect of Centella asiatica L. extract was studied against genotoxic doses of ethinylestradiol on human lymphocytes culture. The different doses of C. asiatica L. extract i.e. 1.075x10-4, 2.125x10-4 and 3.15x10-4 g/ml were treated separately with 5 μM of ethinylestradiol. Similar treatments were given with 10 μM of ethinylestradiol. The treatments result in a significant dose ...
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تاریخ انتشار 2013